AKT1 and thyroid cancer: As a major member of dibenzocyclooctadiene lignans, Sch A not only impaired the proliferation, migration, and invasion of breast cancer, ovarian cancer, and thyroid cancer through prompting ER stress, inactivating Akt signals, and down-regulating miR-429, but also acted as a favorable chemosensitization agent in breast cancer and colon carcinoma [18,19,39,40].