Accumulating evidence shows that HSF1 exerted strikingly multifaceted effects on the carcinogenesis process of a variety of hematologic and solid tumor malignancies (e.g., T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, breast cancer, gastric cancer, CRC, and so on). This evidence concerns the gene HSF1 and B-cell chronic lymphocytic leukemia.