Moreover, m6A-YTHDF2-FTO signaling way might be crucial for the development of obesity, m6A—binding protein YTHDF2 can methylate mRNAs of cyclin A2 (CCNA2) and cyclin dependent kinase 2 (CDK2), and then reduce their protein expression to prolong cell cycle progression and suppress adipogenesis [90]. This evidence concerns the gene CDK2 and obesity due to melanocortin 4 receptor deficiency.