METTL3 and osteoporosis: Also, the deletion of METTL3 in bone marrow mesenchymal stem cells disrupts cell fate and promotes osteoporosis pathological phenotypes (decreasing bone mass with incompetent osteogenic potential and increasing marrow adiposity with enhanced adipogenic potential) by reducing m6A methylation level in mice via parathyroid hormone (PTH)/parathyroid hormone 1 receptor (PTH1R) signaling axis [118].