Intriguingly, the levels of m6A methyltransferases (METTL3, METTL14, WTAP) mRNA expression are also significantly elevated in patients with T2D, but the expression of METTL3, METTL14, and KIAA1429 are negatively correlated with m6A content [32]. This evidence concerns the gene METTL3 and type 2 diabetes mellitus.