Not surprisingly, a number of proteins involved in tumor cell dissemination and BBB invasion were also found to associate with BCBM progression, including cathepsin-S [85], S100A4 [68], RANKL, RANK, Src [65], HYAL1, HAS2 [77] and prominin-1 (CD133) [37]. The gene discussed is PROM1; the disease is neoplasm.