When we investigated the possibility to develop gene therapy for acute kidney injury (AKI) by delivery of Hsp/c70 [15] expressing plasmid to an AKI mouse model, induced by HgCl2 [16] or by cisplatin (unpublished), we unexpectedly found that the control empty NCs functioned better than the Hsp70 vector. The gene discussed is HSP90B2P; the disease is acute kidney injury.