To investigate if pDCs prevent latent infection via a dominant negative effect, we infected CD4+ T cells in the presence of mDCs and the pDCs were added back to the CD4+ T cell—mDC co-cultures at decreasing ratios of pDC to mDC (ranging from 1:1 to 1:1000). The gene discussed is CD4; the disease is disease arising from reactivation of latent virus.