Given that pDC produce abundant type I IFN [33] and type III IFNs [34], here we investigated how pDC modulate HIV latency in CD4+ T cells and studied the effect of individual type I and III IFNs on the establishment of latent infection as well as the effect of different IFNs on latently infected cells. Here, CD4 is linked to disease arising from reactivation of latent virus.