To evaluate whether hedgehog signalling pathway mediates drug sensitivity through TAP1 in poorly differentiated hepatoma cells, Huh‐7‐trans and Huh‐7‐DN with GLI1‐KD or TAP1‐KD were treated with Sorafenib, doxorubicin or cisplatin at a concentration gradient for 24 hours. This evidence concerns the gene GLI1 and hepatocellular carcinoma.