EPCAM and hepatocellular carcinoma: These two subpopulations displayed enhanced chemo‐resistance and invasive behaviour compared with their counterparts.4, 5 Our further study demonstrated that Hh signalling transcription factor GLI2 modulates drug resistance in Huh‐7‐DN cells through ABCC1 (ATP‐binding cassette, ABC subfamily C member 1).5 Therefore, it is intriguing to explore whether the Hh signalling controls drug resistance in poorly differentiated hepatoma cells with a negative CD133/EpCAM surface marker profile through a particular molecular mechanism.