To assess the clinical relevance between the hedgehog signalling activation and TAP1, expression of GLI1 and TAP1 was detected in 12 pairs of HCC specimens and pericancerous tissues, including 8 HBV‐associated HCC, 1 fatty liver‐associated HCC and 3 cases with unknown base disease. The gene discussed is GLI1; the disease is hepatocellular carcinoma.