In this context, both hedgehog signalling pathway and TAP1 could be valuable molecular targets for improving the outcome of chemosensitivity of a poorly differentiated type of HCC, which features with often both CD133‐ and EpCAM‐negative, exhibits marked EMT properties and possesses a devastating prognosis.3, 4. The gene discussed is PROM1; the disease is hepatocellular carcinoma.