With regard to PRS, age > 55 years (hazard ratio [HR]: 1.60, 95% confidence interval [CI]: 1.00‐2.53, P = .048), the presence of hepatitis (HR: 2.78, 95% CI: 1.41‐5.26, P = .003), time to recurrence >2 years (HR: 0.31, 95% CI: 0.19‐0.51, P < .001), serum AFP level at recurrence >20 ng/mL (HR: 2.04, 95% CI: 1.30‐3.21, P = .002), and treatment allocation (HR: 0.47, 95% CI: 0.29‐0.77, P = .002) were identified as significant factors in the univariate analysis. The gene discussed is AFP; the disease is hepatitis A virus infection.