It has been shown that neutrophil‐derived EVs are abundant in the SF of RA, and that they overexpress the proresolving, anti‐inflammatory protein annexin A1 (AnxA1); the addition of these EVs to chondrocyte cultures in vitro led to the activation of anabolic pathways and cartilage protection. This evidence concerns the gene ANXA1 and rheumatoid arthritis.