In lung squamous cell carcinoma (LSCC) tumor-spheres [29], SOX2 activation induced upregulation of Hh acyltransferase (HHAT) [30], a critical component that palmitoylates Hh ligands, and induced autocrine pathway activation to drive growth of LSCC tumor-spheres but not bulk LSCC cells nor LAD tumor-spheres [29]. The gene discussed is SOX2; the disease is neoplasm.