Dysfunction in PCP can lead to the abnormal activation of the developmental pathway and ultimately promotes tumor progression.28 Previous study have found that VANGL2 was upregulated in transcripts of ovarian and uterine cancer, and high expression levels are associated with poor prognosis in patients with breast cancer and GBM.29, 30, 31 In contrast, we found that the overexpression of circ‐IGF1R in lung cancer (specifically A549 and PC9 cell lines) resulted in the consistent upregulation of VANGL2 expression, which inhibited the invasion and migration of lung cancer cells. Here, IGF1R is linked to neoplasm.