The expression level of VANGL2 increased due to the overexpression of circ‐IGF1R, and the expression levels of CTNNB1 and vimentin were reduced, which revealed that an increase in VANGL2 expression may inhibit the Wnt/β‐catenin pathway in lung cancer cells, which in turn affects cancer cell invasion and migration. This evidence concerns the gene CTNNB1 and cancer.