In the CCR4‐IL2 IT group (Fig. 7E,J), no tumor cell areas were identified in the examined section of the liver (see Fig. 7E), demonstrating that both the IL2‐CCR4 and CCR4‐IL2 bispecific ITs more effectively depleted the human CD25+CCR4+ tumor cells than IL2 fusion toxin or CCR4 IT. Here, CCR4 is linked to neoplasm.