BCL2 and breast cancer: The results showed that the expression levels of Bax was significantly upregulated, while the expression of Bcl‐2 protein was reduced, which suggesting that hinokiflavone probably induce apoptosis in breast cancer cells via mitochondrial apoptosis pathway.27, 28 For the purpose of investigating the effect of hinokiflavone on the metastatic ability of breast cancer cells, we conducted transwell migration and invasion experiments.