APP and Alzheimer disease: While there are reports that the power of theta oscillations was reduced in transgenic mouse models of AD such as 3xTg ex vivo (Mondragon-Rodriguez et al. 2018), CRND8 ex vivo (Goutagny et al. 2013), APP/PS1 in vivo (Wang et al. 2002; Scott et al. 2012), APP23 in vivo (Ittner et al. 2014), one study reported that theta oscillations during spatial navigation in awake behaving mice was unaffected in 5XFAD mice in vivo (Zhang et al. 2016).