SST and Alzheimer disease: After confirming that the AβO-injected mice model can reliably replicate hippocampal theta and gamma oscillation impairments as observed in other studies AD (Driver et al. 2007; Iaccarino et al. 2016; Ittner et al. 2014; Mondragon-Rodriguez et al. 2018; Palop and Mucke 2016; Villette et al. 2010; Wang et al. 2002), we next investigated the effect of optogenetic activation of SST interneurons on theta and gamma oscillations in AβO-injected SST-Cre mice.