ABO and Alzheimer disease: Similarly, transgenic mice that model AβO-related pathologies of AD (Wang et al. 2002; Iaccarino et al. 2016; Verret et al. 2012; Martinez-Losa et al. 2018; Tomiyama et al. 2010) show impairments to synaptic plasticity (Chapman et al. 1999; Rowan et al. 2003; Larson et al. 1999; Tomiyama et al. 2010) and memory functions (Brouillette et al. 2012; Kim et al. 2014; Tomiyama et al. 2010).