The estimated BC relative risk was 1.99 (95% CI = 1.39 to 2.85; P = 1.55 × 10-4) for RAD51C and 1.83 (95% CI = 1.24 to 2.72; P = .002) for RAD51D pathogenic variant carriers when relative risk was constant with age (Table 2). Here, RAD51D is linked to breast cancer.