Similarly, the predicted cumulative risk of developing BC to age 80 years varies from 20% (95% CI = 15% to 28%) for RAD51C and 19% (95% CI = 13% to 27%) for RAD51D pathogenic variant carriers with an unaffected mother at age 50 years and unaffected maternal grandmother at age 70 years to 46% (95% CI = 6% to 56%) for RAD51C and 44% (95% CI = 33% to 55%) for RAD51D pathogenic variant carriers with two first-degree relatives diagnosed with BC (Figure 2;  Supplementary Tables 10 and 11, available online). Here, RAD51C is linked to breast cancer.