AK3 and open-angle glaucoma: Interestingly, a recent study showing association of mitochondrial proteins with the pathogenesis of POAG identified a number of key genes including Atp5h, Cox17, Ndufs7, Ndufb9, Uqcrc1 and Ak3 involved in oxidative phosphorylation in human POAG that were identical to some of the genes observed in our findings57.