Considering that inflammation of the adipose organ is one of the key links between obesity and developing glucose intolerance15,34,35, we anticipate similarly impaired response between the control and AIF1L KO mice upon glucose challenge, based on the similar quantitation of crown like structures shown in Supplementary Fig. S5, one of the markers of inflammation. The gene discussed is AIF1L; the disease is obesity due to melanocortin 4 receptor deficiency.