KDR and neoplasm: Of note, rs1870377 (KDR, VEGFR2, NM_002253.3:c.1416A>T) induces a missense substitution Q472H in the fifth (out of seven) extracellular Ig-like motifs that has been shown to increase VEGF-A binding and activity inducing increased microvessel density in tumor tissue of patients with non-small cell lung cancer30.