In previous reports on ADSNHL hearing loss, the progression rate for the POU4F3 gene was 0.5–0.9 dB/year41, that for MYO6 was 2.0 dB/year45, and that for ACTG1 was 2.0–6.0 dB/year46, and the results in this study suggests that the rate of hearing loss progression caused by EYA4 may be relatively mild. This evidence concerns the gene POU4F3 and hearing loss disorder.