Among the deregulated genes involved in the EMT signaling, CTNNB1, as well as JAK1 play key roles in colon cancer progression: CTNNB1 through the activation of Wnt/β-catenin signaling, and JAK/STAT pathway by regulating cell survival and proliferation, differentiation and migration72. Here, CTNNB1 is linked to malignant colon neoplasm.