Among the deregulated genes involved in the EMT signaling, CTNNB1, as well as JAK1 play key roles in colon cancer progression: CTNNB1 through the activation of Wnt/β-catenin signaling, and JAK/STAT pathway by regulating cell survival and proliferation, differentiation and migration72. The gene discussed is JAK1; the disease is malignant colon neoplasm.