Gene set enrichment analysis on striatum-specific differentiated genes revealed that most downregulated genes are involved in calcium transport or calcium transmembrane transport (Supplementary Fig. 3d, k) or associated with striatal degeneration, mental retardation, dyskinesia, ataxia, and epilepsy (such as Camk2b, Pde10a, Kcnab1, Tomm70a, and Cacna2d3; Supplementary Data 1). The gene discussed is PDE10A; the disease is Ataxia.