These include its conserved nature in animals and likely presence in earlier organisms (36), links between mutations in the AspH encoding genes to inherited diseases (9, –, 11), links of AspH to cancer (13, 15, –, 17), mouse model studies (12), and analytical studies revealing extensive hydroxylation of (likely) AspH-catalyzed hydroxylation of EGFDs (3, 5, –, 7, 67). Here, ASPH is linked to hereditary disease.