High CEA level (OR = 1.684, 95% CI = 1.040–2.725), RLL tumors (OR = 2.111, 95% CI = 1.116–3.992) and station 11 involvement (OR = 1.774, 95% CI = 1.056–2.980) were independent risk factors for NLSLNM, while hypertension (OR = 0.512, 95% CI = 0.286–0.918) was a protective factor for NLSLNM. The gene discussed is CEACAM5; the disease is Hypertension.