ALOX15 and colorectal cancer: miR-522 was predicted to interact with ALOX15 mRNA, and the binding region was shown in Supplemental Figure 3D. It was reported that miR-522 promotes tumor progression in non-small cell lung cancer, colorectal cancer and hepatocellular carcinoma [32–34], but the role of miR-522 in gastric cancer has not been well defined yet.