While when YTHDF2 interacts with oncogenes then inhibits cell growth; unknown molecular mechanisms that higher expressions of YTHDF1 were in tumor tissues while higher expressions of YTHDF2 were in normal tissues of NSCLC; whether the regulatory mechanism mentioned above of ALKBH5 and YTHDFs applies to other genes or is limited to YAP need to be further explored. Here, YTHDF1 is linked to non-small cell lung carcinoma.