While when YTHDF2 interacts with oncogenes then inhibits cell growth; unknown molecular mechanisms that higher expressions of YTHDF1 were in tumor tissues while higher expressions of YTHDF2 were in normal tissues of NSCLC; whether the regulatory mechanism mentioned above of ALKBH5 and YTHDFs applies to other genes or is limited to YAP need to be further explored. This evidence concerns the gene ALKBH5 and non-small cell lung carcinoma.