For example, ALKBH5 holds prognostic value and inhibits the metastasis of colon cancer [8]; ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of Cyr61 mRNA [9]; METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, dictating the fate of hypoxia/reoxygenation-treated cardiomyocyte [10]; ALKBH5 inhibits pancreatic cancer cell motility by decreasing methylation of the long non-coding RNA KCNK15-AS1 [11]. Here, ALKBH5 is linked to colonic neoplasm.