IL6 and Hyperglycemia: This is in contrast to the partial responders in the triple combination treatment (anti-TCR plus anti-IL-6 and anti-IL-17), where the glucose concentrations showed a partial reduction of hyperglycaemia from an initial high blood glucose concentration of 18.1 ± 0.3 mmol/l (n = 2) to a value to 9.1 ± 0.2 mmol/l (n = 2) and a value of 12.3 ± 3.3 mmol/l (n = 2) 60 days after therapy along with a partial increase of the beta cell mass (Fig. 2c) and a partial increase of the C-peptide levels (Fig. 1e).