Therefore, we analysed in the present study in the LEW.1AR1-iddm rat (short name: IDDM rat), a model of human T1D, after disease manifestation, the preventive potential of a rat-specific antibody against IL-17A, anti-IL-17A, which was successfully used in the therapy of experimental rheumatoid arthritis [22] and a monoclonal rat-specific antibody against IL-6, anti-IL-6, which was successfully administered in a rat hypertension model with kidney inflammation [23]. This evidence concerns the gene IL6 and rheumatoid arthritis.