Among the 191 cases of lung cancer, the high expression rate for syntenin was 57.0% in 121 cases where the diameter of tumours was greater than 3 cm, while the high expression rate was 34.3% in 70 cases where the diameter of tumours was less than or equal to 3 cm, and the difference was statistically significant (P = 0.002). The gene discussed is SDCBP; the disease is neoplasm.