Moreover, multivariate COX proportional hazard regression analysis demonstrated that distant metastasis (P < 0.001 for OS and PFS), lymph node metastasis (P = 0.005 and = 0.004 for OS and PFS, respectively), syntenin expression (P = 0.006 and < 0.001 for OS and PFS, respectively) and performance status (P < 0.001 for OS and PFS) were independent risk factors for poor prognosis. This evidence concerns the gene SDCBP and metastatic malignant neoplasm in the lymph nodes.