Our results suggest that the status of GR, Sgk1, and NDRG1 in ESCC patients undergoing NAC was significantly related to the treatment outcomes and that the GR-Sgk1-NDRG1 pathway in carcinoma cells of ESCC might be involved in the clinical effects of chemotherapy in these patients. This evidence concerns the gene NR3C1 and esophageal squamous cell carcinoma.