recently reported that individuals with isolated IgA anti-β2GPI but without history of APS events had more APS-related events, mainly arterial thrombosis, during 5-year follow-up compared with individuals negative for aPL.41 However, it is noteworthy that risk stratification using the antiphospholipid score (aPL-S)42 and/or the global APS score (GAPSS)43 does not involve IgA aPL. The gene discussed is FASLG; the disease is Arterial thrombosis.