IgA has been described to be the most prevalent aPL isotype in populations of African origin.10,16, , –19 In parallel, our group recently reported a predominance of IgA RF in Sudanese rheumatoid arthritis patients.45 In the current study, the high levels and prevalence of IgA anti-CL and anti-β2GPI in Sudanese pregnant females was not associated with increased IgA RF levels, arguing against a general IgA increase in these women but instead indicating an antigen-specific increase in IgA aPL. This evidence concerns the gene APOH and rheumatoid arthritis.