By integrating with previous reports, we then proposed a reasonable model to explain the genetic mechanisms underlying FLHS in chickens and further highlighted IL6, SOCS3, and CNTF in the Jak-STAT signaling pathway as potential therapeutic targets for chicken FLHS, though further studies are needed to confirm the proposed model and highlighted candidate genes for the FLHS disease in laying hens. Here, CNTF is linked to Floating-Harbor syndrome.