Astrocyte reactivity is initially characterized by hypertrophy of soma, hyperplasia, and, notably, an increase in the expression of glial fibrillary acidic protein (GFAP) and vimentin [19] In glaucoma patients [20,21,22] as well as in preclinical models of glaucoma, astrocyte reactivity was reported at the retina level. Here, VIM is linked to glaucoma.