Cyclin E1 protein levels are regulated by the SCF complex [38,39,40], and although many studies have established strong causal links between genomic amplification of CCNE1 and many cancer types (e.g., breast, liver and ovarian) [41,42,43,44], there is a paucity of information pertaining to the misregulation and ensuing overabundance of CCNE1 protein levels resulting from defects in the SCF complex. This evidence concerns the gene CCNE1 and cancer.