ARL2, BUB3, DSN1, NUF2 and SPC24 encode functions in mitosis with specific roles in mitotic spindle assembly, microtubule dynamics, and kinetochore-microtubule attachments [10,11,12], while GART (de novo purine biosynthesis [13]), SHMT2 (de novo thymidylate biosynthesis [14]), GARS (glycyl-tRNA synthesis [15]), PIGS (GPI-anchor biosynthesis [16]) and SKP1 (ubiquitin-mediated proteasomal degradation [17]) encode functions that are not immediately linked to CIN and were purposefully selected to gain insight into novel mechanisms responsible for CIN. Here, SKP1 is linked to cervical squamous intraepithelial neoplasia.