Our data further suggest that hypomorphic mutations in the remaining SCF complex member genes (i.e., RBX1, CUL1 and FBOX proteins) may also be pathogenic events, as similar outcomes on CCNE1 levels and CIN are expected to occur as a result of aberrant SCF formation and function. The gene discussed is CUL1; the disease is cervical squamous intraepithelial neoplasia.