More specifically, we sought to determine whether co-silencing SKP1 and CCNE1 (siSKP1 + siCCNE1) would limit the CIN phenotypes observed when SKP1 was silenced alone (siSKP1) or in combination with a negative control (siSKP1 + siControl). This evidence concerns the gene CCNE1 and cervical squamous intraepithelial neoplasia.