In addition, emodin sensitizes resistant tumor cells to chemotherapeutic agents such as tumor necrosis factor (TNF)-related apoptosis-inducing ligands, as oxaliplatin, gemcitabine, adriamycin, cisplatin, capecitabine, paclitaxel, abiplastin, doxorubicin, and 5-fluorouracil. This evidence concerns the gene TNF and neoplasm.