Our results, suggesting that ticagrelor may counteract SIRT1 reduction in RNA from peripheral blood of stable CAD/COPD patients, are consistent with previous reports of reduced activity of SIRT1 in serum of COPD patients [39] and inhibition of SIRT1 gene in peripheral monocytes in ACS and stable CAD patients [38]. This evidence concerns the gene SIRT1 and chronic obstructive pulmonary disease.