In order to gain more insights on the molecular pathways modulated by ticagrelor, we determined, in RNA isolated from peripheral blood cells of stable CAD patients following PCI, the effect of 1-month treatment with ticagrelor or clopidogrel on mRNA expression levels of inflammation- and oxidative stress-related genes, such as ICAM1, NLRP3, SIRT1, JAG1, DLL4, HES1, RORγt (Th17 marker), and FoxP3 (Tregs marker). This evidence concerns the gene HES1 and coronary artery disorder.