We compared the mRNA expression levels of RORγt (Th17 cells transcription factor), FoxP3 (Tregs transcription factor), NLRP3, ICAM1, SIRT1, Notch ligands JAG1 and DLL4, and of HES1, Notch target gene, in RNA isolated from peripheral blood cells obtained from stable CAD/COPD patients following PCI before (T0) and after 1-month (T30) treatment with ticagrelor or clopidogrel. The gene discussed is NLRP3; the disease is coronary artery disorder.