The negative correlation found in this study may be suggestive of a cross-talk among EGF, SIRT1, and/or HES1 in peripheral blood of stable CAD/COPD patients, according to which ticagrelor-mediated EGF-reduction may lead to the induction of SIRT1/HES1 axis. This evidence concerns the gene HES1 and chronic obstructive pulmonary disease.