Another limitation is the lack of information on the deacetylase activity of SIRT1 in our samples that, as shown by Conti and collaborators, would have provided more specific information, compared to the mRNA, about the role of SIRT1 [39] in mediating the pleiotropic effects of ticagrelor in stable CAD/COPD patients. Here, SIRT1 is linked to chronic obstructive pulmonary disease.