The Notch pathway is regulated by cross-talks with a plethora of pathways [34,35] including the NAD+-dependent protein deacetylase, sirtuin1 (SIRT1), an oxidative stress sensor [36] and a repressor of inflammatory response [37], whose expression and activity is reduced in peripheral blood mononuclear cells (PBMCs) of stable CAD, ACS [38], and COPD [39] patients. This evidence concerns the gene SIRT1 and chronic obstructive pulmonary disease.