NFE2L2 and esophageal squamous cell carcinoma: There are many studies showing elevated expression of NRF2 in various types of tumors such as non-small cells lung cancer (NSCLC), esophageal squamous cell cancer (ESCC), gastric cancer (GC), head and neck cancer (HNC), breast cancer (BC), ovarian cancer (OC), and endometrial cancer (EC) [46].