KEAP1 and neoplasm: As first, Apigenin was seen to reduce the expression of NRF2 and its targets HO-1, AKR1B10 and MRP5 both at the mRNA and protein levels in a KEAP1-independent way, by downregulating the PI3K/AKT pathway and to strongly sensitize BEL-7402/ADM cells to Doxorubicin both in vitro and in vivo, blocking tumor growth [344].