In this regard, NRF2 was shown to enhance the expression of key enzymes for serine/glycine biosynthesis such as PHGDH (Phosphoglycerate Dehydrogenase), PSAT1 (Phosphoserine Aminotransferase 1), PSPH (Phosphoserine Phosphatase) and SHMT1-2 (Serine Hydroxymethyltransferase 1-2) in a panel of NSCLC cells [167]. The gene discussed is PSPH; the disease is non-small cell lung carcinoma.