Indeed, by using H1437, A549 NSCLC and DU145 PC cells, Singh et al., reported that genetic induction of PPP genes was mediated by NRF2-dependent repression of miR-1 and miR-206, two negative regulators of G6PD, PGD and TKT expression, through yet unknown epigenetic mechanisms involving the histone deacetylase HDAC4 [240]. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.