Similarly, Singh et al., conducted a quantitative high-throughput screening (qHTS) of the Molecular Libraries Small Molecule Repository (MLSMR) and identified a compound named ML385 that was able to reduce the transcriptional activity of NRF2 by preventing the binding of the NRF2-MAFG complex to the ARE sequence in the promoter of NSCLC cells. The gene discussed is NFE2L2; the disease is non-small cell lung carcinoma.