G6PD and breast cancer: Also, other data indicate that NRF2 overexpression or KEAP1 KD can upregulate the mRNA and protein levels of G6PD and TKT, enhancing tumor proliferation, migration and invasion of MCF7 and MDA-MB-231 BC cells by promoting EMT through G6PD/HIF-1α activation of Notch1 signaling, while NRF2 silencing or KEAP1 overexpression reverted these changes [215].