Of note, AEM1 was also able to decrease the NRF2-dependent induction of HMOX1 in H838 and H460 NSCLC cells with LOF mutations of the KEAP1 gene, suggesting that AEM1 might preferentially target tumor cells with constitutive NRF2 activation [336]. The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.