NFE2L2 and colorectal carcinoma: Indeed, NRF2 was seen to enhance the ATF4 transcriptional activity in autophagy-deficient HCT116 CRC cells, promoting the expression of genes (SLC6A9, SLC36A4, SLC38A1, and SLC38A3) codying for AATs (aminoacid transporters) involved in the uptake of glycine and glutamine.