NFE2L2 and neuroblastoma: Initial studies on solid tumors have shown that All-Trans Retinoic Acid (ATRA) can induce RARα expression, which in turn forms a protein complex with NRF2 and antagonizes its transactivation [347,348], sensitizing chemoresistant neuroblastoma (NB) HTLA-230 cells to the proteasome inhibitor Bortezomib [349].