ME1 and hepatocellular carcinoma: Interestingly, some studies suggest that NRF2 can control the expression of NADPH-producing enzymes involved in one-carbon metabolism such as MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2) or in the TCA cycle, such as IDH1 (Isocitrate Dehydrogenase 1) and ME1 (Malic enzyme 1) [53,239,243], while others indicate that NRF2-dependent induction of the folate-cycle enzyme MTHFDL1 (Methylenetetrahydrofolate Dehydrogenase 1-like) can increase the NADPH levels in HCC cells, supporting proliferation and redox homeostasis [58].