On the other hand, mice deficient in IFNAR1 are susceptible to ZIKV infection [61] and it has been demonstrated that systemic ZIKV spreading relies on IFNAR1 expression in the hematopoietic compartment, whereas spreading within the CNS requires IFNAR1 expression on non-hematopoietic cells [62]. The gene discussed is IFNAR1; the disease is Zika virus infectious disease.