CD8A and Zika virus infectious disease: In addition, a rare case of ZIKV infection during pregnancy in association with Guillain-Barré syndrome revealed an increase in placental inflammation and dysfunction with high cellularity (Hofbauer cells and T CD8+ lymphocytes) in tissue, and high expression of local proinflammatory cytokines such as IFN-γ and TNF-α, and other markers, such as RANTES/CCL5 and VEGFR2.