EIF2AK2 and hepatocellular carcinoma: However, further investigations are needed to assess (i) how many other recently treated patients will still develop HCC in a longer follow-up, (ii) the correlation between ISDR or PKR-bd substitutions and development in HCC, (iii) the correlation between advanced fibrosis after SVR and HCC development, and (iv) which genotype will be the most prone to develop HCC.