CASP3 and melanoma: Some reports showed that gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and caspase-independent pathways, and quercetin induces apoptosis in a caspase-3-dependent pathway in leukemia cell line (HL-60), while kaempferol was found to bind with caspases through an allosteric mode of competitive inhibition using both in silico computer docking technique and in vitro assay [23,24,25].