Klotho-deficient CKD mice had more pronounced cardiac hypertrophy than wild-type CKD mice and even after normalization of serum phosphate and FGF23 levels, cardiac hypertrophy was not improved, meaning that klotho-deficiency is an important cause of cardiac hypertrophy in CKD, independently of FGF23 and phosphate [112]. The gene discussed is FGF23; the disease is chronic kidney disease.