Examples of such “Achilles” heel include midbrain dopaminergic neurons in Gaucher disease [130], Purkinje cells in NPC1 and α-mannosidosis [131,132], medium spiny GABAergic neurons in GM1 gangliosidosis [133], hippocampal neurons (from the dentate gyrus and CA3) in MPS and NCL, and cortical pyramidal neurons in NCL, Tay-Sachs and MPS [65,85,134,135]. Here, NPC1 is linked to mucopolysaccharidosis.