The allelic loss and somatic mutations of KLF6 were observed in patients with sporadic prostate cancer and a germline single nucleotide polymorphism (SNP) in KLF6 gene IVS1-27 G > A is shown to cause aberrant splicing to generate 3 splice variants, KLF6-SV1, -SV2 and -SV3. This evidence concerns the gene KLF6 and Familial prostate cancer.