It is indicated that an acetyltransferase CBP could regulate Sam68 acetylation [110], while histone deacetylase 6 (HDAC6) causes Sam68 deacetylation in cooperation with a nuclear matrix-associated protein, scaffold/matrix-associated region-binding protein 1 (SMAR1), in breast cancer [111]. The gene discussed is KHDRBS1; the disease is breast cancer.