Chromothripsis has also been suggested as a common mechanism leading to genomic rearrangements in colorectal cancer, leading to the deletion or truncation of several tumor suppressor or other cancer-related genes [23]; however, it was not specified whether the patients had germline variants in the MMR genes (MLH1, MSH2, MSH6, and PMS2), which are commonly associated with hereditary nonpolyposis colorectal cancer [39]. Here, MRC1 is linked to colorectal cancer.