The lincRNA-p21 was identified by tiling microarrays performed from p53 activation following DNA damage in mouse embryonic fibroblasts (MEFs) and lung cancer cells derived from mice express KRAS.LincRNA-p21 is a first broadly studied p53-induced lncRNA well characterized as a crucial regulator of the p53 network [26]. This evidence concerns the gene CDKN1A and lung cancer.