Conversely, the top-200 genes that negatively correlated with TOX exhibited significant overlap with post-GC B-cell signatures, including down-regulated signatures in FL (compared to reactive lymph node or NMZL either), IRF4 programme in myeloma and plasma cells and MYD88 up-regulated transcriptome (S3 Fig in S1 Text). This evidence concerns the gene MYD88 and plasma cell myeloma.