Another possibility is raised by the finding that double knockout of Tox and Tox2 in chimeric antigen receptor (CAR) modified T cells infiltrating tumors affected the NF-κB pathway, including the increased accessibility of chromatin regions enriched for motifs that bind NF-κB [25].It is therefore also possible that suppressing TOX function may contribute to activation of NF-κB signaling, which is critical for the survival of the ABC-DLBCL subtype [25]. Here, TOX2 is linked to diffuse large B-cell lymphoma.