A total of 27 predicted genes were associated with NAFLD development or progression, including multi-functional cellular mechanisms or signaling pathways (HDAC2), fibrosis and inflammation (CAT, CTGF, IL10, PDGFA, PDGFRA, SMAD4, TGFBR1, and THBS1), cell survival and proliferation (Bcl2, CCNB1, HGF, PMAIP1, PTEN, and YAP1), and energy management, including gluconeogenesis and lipogenesis (CREB1, EIF4E, FOXO1, INSR, IGF1, IGF1R, ITPR2, PRKAA1 and 2, RICTOR, SOCS1, and TCF7L2) (Table 4) [35–60]. The gene discussed is CREB1; the disease is metabolic dysfunction-associated steatotic liver disease.