Among these novel lncRNAs, transcripts that are transcribed antisense to myocardial transcription factors, such as GATA4, GATA6, and KLF6, were identified and observed to potentially have important biological functions in the heart.72 An experimentally validated database (a heart disease-related, noncoding RNA database, HDncRNA) developed by Wang et al contains around 2000 lncRNAs that are associated with heart diseases in 6 species, including humans, rodents, pigs, calves, and dogs. The gene discussed is KLF6; the disease is heart disorder.