SiRNA‐mediated down‐regulation of SEZ6L2 prevents phosphorylation of adducin and neuritogenesis.19 Higher SEZ6L2 expression predicts a poor prognosis for NSCLC, but the function of SEZ6L2 in cancer was still unclear.12 In this study, the in vitro and in vivo results suggested that SEZ6L2 functioned as an oncogene in CRC. Here, SEZ6L2 is linked to non-small cell lung carcinoma.