Apoptosis was induced through caspase‐dependent and caspase‐independent pathways in diverse cells.20 We found that the knockdown of SEZ6L2 promotes the apoptosis of CRC cells by inducing the expression of caspase 3 and caspase 9 but has no significant impact on the expression of caspase 8. The gene discussed is CASP8; the disease is colorectal carcinoma.