Apoptosis was induced through caspase‐dependent and caspase‐independent pathways in diverse cells.20 We found that the knockdown of SEZ6L2 promotes the apoptosis of CRC cells by inducing the expression of caspase 3 and caspase 9 but has no significant impact on the expression of caspase 8. Here, SEZ6L2 is linked to colorectal carcinoma.