CDCA5, DNMT1, UNKL, HSPD1, KLC1, CBX2, RPMS17, LAMB1, SLC3A2, PARP12 and COMMD10 were selected as the hub genes, and elucidation of the function of these hub genes might provide new insights into the molecular mechanisms of miR‐542‐5p in osteosarcoma. Here, DNMT1 is linked to osteosarcoma.