CBX2 and osteosarcoma: CDCA5, DNMT1, UNKL, HSPD1, KLC1, CBX2, RPMS17, LAMB1, SLC3A2, PARP12 and COMMD10 were selected as the hub genes, and elucidation of the function of these hub genes might provide new insights into the molecular mechanisms of miR‐542‐5p in osteosarcoma.