These AKG sensors include hypoxia‐inducible factor prolyl‐hydroxylases (PHDs), ten‐eleven translocations (TETs), lysine demethylase 6B (JMJD3), octamer‐binding transcription factor 4 (OCT4), ankyrin repeat, SAM and basic leucine zipper domain containing 1 (ASZ1), WAP four‐disulfide core domain 15A (wdfc15a), depleted in azoospermia‐like (Dazl), and its endogenous G protein‐coupled receptor (OXGR1) (Zdzisinska et al, 2017). This evidence concerns the gene POU5F1 and Azoospermia.