To assess if OXGR1AG is sufficient to mediate the anti‐obesity effects of AKG, we generated an OXGR1 adrenal‐selective reexpression (OXGR1REAG) mouse model by delivering HBAAV2/9‐OXGR1 virus into the adrenal gland of OXGR1KO mice. Here, OXGR1 is linked to obesity due to melanocortin 4 receptor deficiency.