Compared with the DM group, the DM+cerebral ischemia group had significantly increased expression of VEGF in the retinal tissue of tree shrews (P < 0.01), suggesting that cerebral ischemia can enhance the expression of VEGF in diabetic tree shrew, while in the DM+cerebral ischemia+ischemic PC group, the thickness of the retina layers was close to that of normal retina and the morphology of pigmented cells was normal. Here, VEGFA is linked to brain ischemia.