When adjusted for age, duration of T2DM, gender, smoking rate, BMI, the usage of insulin and metformin, hypertension, HbA1c, TG, and TC (Model2), the ORs (95% CI) for DR in FT3-Q2, FT3-Q3, and FT3-Q4 were 0.587 (0.340–1.012), 0.458 (0.258–0.813), and 0.368 (0.201–0.673) (P=0.055, P=0.008, P=0.001, respectively). The gene discussed is INS; the disease is type 2 diabetes mellitus.